PubMed listing for June L. Round, Ph.D.

T cell-mediated regulation of the microbiota protects against obesity

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL.
. 2019 Jul 26;365(6451). pii: eaat9351.
PMID: 31346040

The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling

Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL.
Elife. 2019 Jul 16;8. pii: e47117.
Free Article

Does MHC heterozygosity influence microbiota form and function?

Khan MAW, Stephens WZ, Mohammed AD, Round JL, Kubinak JL.
PLoS One. 2019 May 16;14(5):e0215946.  eCollection 2019.
Free PMC Article

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM.
PLoS Genet. 2019 Feb 15;15(2):e1007970. eCollection 2019 Feb.
Free PMC Article

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round JL.
Cell Host Microbe. 2019 Feb 13;25(2):285-299.e8.

MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers.

Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, O'Connell RM.
JCI Insight. 2019 Mar 21;4(6). pii: 126543. eCollection 2019 Mar 21.
Free PMC Article

Fiber Puts Lactobacillus to SLEep.

Chiaro TR, Round JL.
Cell Host Microbe. 2019 Jan 9;25(1):3-5.

Gut microbiota: a new way to take your vitamins.

Gomes-Neto JC, Round JL.
Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):521-522. No abstract available.

Communication Between the Microbiota and Mammalian Immunity.

Ost KS, Round JL.
Annu Rev Microbiol. 2018 Sep 8;72:399-422. Epub 2018 Jun 21.

Commensal regulation of T cell survival through Erdr1.

Weis AM, Soto R, Round JL.
Gut Microbes. 2018;9(5):458-464. Epub 2018 Apr 11. Review.
Free PMC Article

Causal effects of the microbiota on immune-mediated diseases.

Round JL, Palm NW.
Sci Immunol. 2018 Feb 9;3(20). pii: eaao1603. Review.

Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model.

Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami RS.
Benef Microbes. 2018 Apr 25;9(3):495-513. Epub 2018 Jan 30.
Free PMC Article

IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis.

Whiteside SK, Snook JP, Ma Y, Sonderegger FL, Fisher C, Petersen C, Zachary JF, Round JL, Williams MA, Weis JJ.
J Immunol. 2018 Feb 15;200(4):1457-1470. Epub 2018 Jan 12.
Free PMC Article

Friends in Low Places: Intestinal Commensals Limit Colitis through Molecular Mimicry.

Brown DG, Round JL.
Cell. 2017 Oct 19;171(3):503-505. j.cell.2017.09.053.
Free Article

Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.

Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM.
J Immunol. 2017 Nov 15;199(10):3559-3570. Epub 2017 Oct 4.
Free PMC Article

Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.

Huffaker TB, Lee SH, Tang WW, Wallace JA, Alexander M, Runtsch MC, Larsen DK, Thompson J, Ramstead AG, Voth WP, Hu R, Round JL, Williams MA, O'Connell RM.
J Biol Chem. 2017 Nov 10;292(45):18530-18541. doi: 10.1074/jbc.M117.808121. Epub 2017 Sep 14.
Free PMC Article

A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella.

Ost KS, Round JL.
Immunity. 2017 Jun 20;46(6):977-979. doi: 10.1016/j.immuni.2017.06.010.
Free Article

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

Download PDFSoto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE,Fujinami RS, Bosque A, O'Connell RM, Round JL.
Proc Natl Acad Sci U S A. 2017 May 9. pii: 201619336.
PMID: 28487480

miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response

Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander Download PDFM, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth W, Rao DS, Miles RR, Round JL, Deininger MW, O'Connell RM.
Blood. 2017 Apr 21. pii: blood-2016-09-740209.
PMID: 28432220

A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round JL.
Sci Transl Med. 2017 Mar 8;9(380). pii: eaaf9044.
Erratum in: Sci Transl Med. 2017 May 3;9(388)
PMID: 28275154

Common Yeast May Worsen IBD Symptoms in Crohn’s Disease

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Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activityDownload PDF

Biswas S, McCullough BS, Ma ES, LaJoie D, Russell CW, Garrett Brown D, Round JL, Ullman KS, Mulvey MA, Barrios AM
Chem Commun (Camb). 2017 Feb 14;53(14):2233-2236
PMID: 28144650

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Do antibodies select a healthy microbiota?

Kubinak JL, Round JL
Nat Rev Immunol. 2016 Dec;16(12):767-774
PMID: 27818504


Nature Research Highlight


The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variabilityDownload PDF

Libbey JE, Doty DJ, Sim JT, Cusick MF, Round JL, Fujinami RS
Nutrition. 2016 Jul-Aug;32(7-8):877-83
PMID: 27133811

Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell GrowthDownload PDF

Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM
PLoS One. 2016 Apr 15;11(4):e0153689
PMID: 27081855

MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection Download PDF

Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL
Nat Commun. 2015 Oct 23;6:8642
PMID: 26494419

MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis Download PDF

Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell RM
Oncotarget. 2015 Oct 6;6(30):28556-72
PMID: 26456940

Innate-like lymphocytes in intestinal infectionsDownload PDF

Bennett MS, Round JL, Leung DT
Curr Opin Infect Dis. 2015 Oct;28(5):457-63 Review
PMID: 26270655

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin Download PDF

Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM
Nat Commun. 2015 Jun 18;6:7321
PMID: 26084661

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MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health

Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O'Connell RM, Round JL
Cell Host Microbe. 2015 Feb 11;17(2):153-63
PMID: 25620548

Selected as a feature paper by the Society for Mucosal Immunology in February 2015

News and Views

miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade InflammationDownload PDF

Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM.
Immunity. 2014 Oct 16;41(4):605-19
PMID: 25367574

MicroRNAs and the regulation of intestinal homeostasisDownload PDF

Runtsch MC, Round JL, O'Connell RM.
Front Genet. 2014 Oct 1;5:347. eCollection 2014. Review
PMID: 25324861

IgA targets the troublemakersDownload PDFenhancing inflammatory T cell development

Stephens WZ, Round JL.
Cell Host Microbe. 2014 Sep 10;16(3):265-7
PMID: 25211066

Defining dysbiosis and its influence on host immunity and diseaseDownload PDFcommensal microbiota

Petersen C, Round JL.
Cell Microbiol. 2014 Jul;16(7):1024-33.
PMID: 24798552

Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulationDownload PDF

Novis CL, Archin NM, Buzon MJ, Verdin E, Round JL, Lichterfeld M, Margolis DM, Planelles V, Bosque A.
Retrovirology. 2013 Oct 24;10:119.
PMID: 24156240

MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expressionDownload PDF

Hu R, Huffaker TB, Kagele DA, Runtsch MC, Bake E, Chaudhuri AA, Round JL, O'Connell RM.
J Immunol. 2013 Jun 15;190(12):5972-80.
PMID: 23686497

Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunityDownload PDF

Huffaker TB, Hu R, Runtsch MC, Bake E, Chen X, Zhao J, Round JL, Baltimore D, O'Connell RM.
Cell Rep. 2012 Dec 27;2(6):1697-709.
PMID: 23200854

Characterization of in vivo Dlg1 deletion on T cell development and functionDownload PDF

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.
PLoS One. 2012;7(9):e45276.
PMID: 23028902

Toll-like receptors promote mutually beneficial commensal-host interactionsDownload PDF

Kubinak JL, Round JL.
PLoS Pathog. 2012;8(7):e1002785. Review.
PMID: 22910541

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiotaDownload PDF

Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK.
Science. 2011 May 20;332(6032):974-7.
PMID: 21512004

MicroRNA-155 promotes autoimmune inflammation by Download PDFenhancing inflammatory T cell development

O'Connell RM, Kahn D, Gibson WS, Round J.L., Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D. (2010)
Immunity. 2010 Oct 29;33(4):607-19.
PMID: 20888269

Inducible Foxp3+ regulatory T cell development by a commensal bacterium of the intestinal microbiota Download PDF

Round JL, Mazmanian SK.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12204-9.
PMID: 20566854

Coordination of tolerogenic immune responses by the Download PDFcommensal microbiota

Round JL, O'Connell RM, Mazmanian SK.
J Autoimmun. 2010 May;34(3):J220-5. Review.
PMID: 19963349

The gut microbiota shapes intestinal immune responses during health and diseaseDownload PDF

Round JL, Mazmanian SK.
Nat Rev Immunol. 2009 May;9(5):313-23. Review.
Erratum in: Nat Rev Immunol. 2009 Aug;9(8):600.
PMID: 19343057

A microbial symbiosis factor prevents inflammatory diseaseDownload PDF

Mazmanian SK, Round JL, Kasper DL.
Nature. 2008 May 29;453(7195):620-5.
PMID: 18509436

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF‐B transcription factorsDownload PDF

Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC.
Nat Immunol. 2007 Feb;8(2):154-61.
PMID: 17187070

Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cellsDownload PDF

Round JL, Tomassian T, Zhang M, Patel V, Schoenberger SP, Miceli MC.
J Exp Med. 2005 Feb 7;201(3):419-30.
PMID: 15699074